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KMID : 0615720010180030079
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Jouranl of Korean Acupuncture and Moxibustion society
2001 Volume.18 No. 3 p.79 ~ p.93
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Study on the Anti - cancer , Anti - metastasis and Immune Response Improvement of Aqua - acupuncture with Amomum Amarum Lourerio Infusion Solution
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Abstract
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Objective : This study was purposed to investigate the anti-cancer and anti-metastasis and immune response of Aqua-acupuncture with Amomum amarum Lourerio infusion solution.
Methods : The Amomum amarum Lourerio infusion solution put into Chung-wan(CV12) of BALB/c or C57BL6 mice were rised to cancer by B15-F10 and HT1080, S-180 cancer celi line.
Results : The following result have been obtained
1. The effect on expression of MMP-9 gene about the HT1080 cancer ceil line was increased in 100, 50 ㎍/㎖ diluent groups, compared with control group.
2. The effect on expression of MMP-9 gene about the B15-F10 cancer cell line was increased in all the sample groups, compared with control group.
3. S-180 cancer cell line transplants in BALB/c mice were inhibited significantly in weight inctease in all the sample groups, compared with control group.
4. The effect on spleen cell proliferation was decreased in all the sample groups, compared with control group.
5. The IFN-γ in all the sample groups and the TNF-α in 25 and 12.5 ㎍/㎖ diluent groups was increased.
6. In flow cytometry, the number of CD4+, CD19+ cell in all the sample group was increased and the number of CD8+ cell in 100㎍/㎖ diluent group, compared with control group.
Conclusion : According to the result, Aqua-acupuncture with Amomum amarum Lourerio infusion solution has significant anti-cancer, anti-metastasis and Immune response improvement.
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